Examines the unfolding of ubiquitin in gas phase, indicating instability and regional stabilization effects.
The structural evolution of ubiquitin after transfer into the gas phase was studied by electron capture dissociation. Site-specific fragment yields show that ubiquitin's solution fold is overall unstable in the gas phase, but unfolding caused by loss of solvent is slowest in regions stabilized by salt bridges.
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Skinner et al. (2012) studied this question.
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