Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish Cohort

LettersOctober 2023Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish CohortKlaus Fuglsang Kofoed, MD, PhD, DMSc, Andreas Fuchs, MD, PhD, Lars Valeur Køber, MD, DMScKlaus Fuglsang Kofoed, MD, PhD, DMScDepartment of Cardiology and Department of Radiology, Copenhagen University Hospital–Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Andreas Fuchs, MD, PhDDepartment of Cardiology, Copenhagen University Hospital–Rigshospitalet, Copenhagen, Denmark, Lars Valeur Køber, MD, DMScDepartment of Cardiology, Copenhagen University Hospital–Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L23-0263 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE: We agree with Dr. Budoff and colleagues that the choice of method for cardiovascular risk stratification of asymptomatic persons to guide preventive treatment strategies requires careful consideration. The aim of our work was to define characteristics of subclinical coronary atherosclerosis evaluated by coronary CTA and assess the possible association with clinical outcome. A randomized controlled trial is needed to change current preventive clinical practice in asymptomatic persons at risk for cardiovascular disease by implementing coronary CTA. We therefore have initiated the DANE-HEART (Computed Tomography Coronary Angiography for Primary Prevention; ClinicalTrials.gov: NCT05677386) trial to evaluate the value of a ...References1. Lindholt JS, Søgaard R, Rasmussen LM, et al. Five-year outcomes of the Danish Cardiovascular Screening (DANCAVAS) trial. N Engl J Med. 2022;387:1385-1394. [PMID: 36027560] doi:10.1056/NEJMoa2208681 CrossrefMedlineGoogle Scholar2. Fuchs A, Mejdahl MR, Kühl JT, et al. Normal values of left ventricular mass and cardiac chamber volumes assessed by 320-detector computed tomography angiography in the Copenhagen General Population Study. Eur Heart J Cardiovasc Imaging. 2016;17:1009-17. [PMID: 26758412] doi:10.1093/ehjci/jev337 CrossrefMedlineGoogle Scholar3. Fuchs A, Kühl JT, Sigvardsen PE, et al. Arterial hypertension and morphologic abnormalities of cardiac chambers: results from the Copenhagen General Population Study. J Hypertens. 2021;39:703-710. [PMID: 33394866] doi:10.1097/HJH.0000000000002705 CrossrefMedlineGoogle Scholar4. Lin A, Manral N, McElhinney P, et al. Deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction: an international multicentre study. Lancet Digit Health. 2022;4:e256-e265. [PMID: 35337643] doi:10.1016/S2589-7500(22)00022-X CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Klaus Fuglsang Kofoed, MD, PhD, DMSc; Andreas Fuchs, MD, PhD; Lars Valeur Køber, MD, DMScAffiliations: Department of Cardiology and Department of Radiology, Copenhagen University Hospital–Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital–Rigshospitalet, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital–Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDisclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M22-3027. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSubclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish Cohort Andreas Fuchs , Jørgen Tobias Kühl , Per Ejlstrup Sigvardsen , Shoaib Afzal , Andreas Dehlbæk Knudsen , Mathias Bech Møller , Martina Chantal de Knegt , Mathias Holm Sørgaard , Børge Grønne Nordestgaard , Lars Valeur Køber , and Klaus Fuglsang Kofoed Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish Cohort Matthew J. Budoff , Khurram Nasir , Michael J. Blaha Metrics October 2023Volume 176, Issue 10 Keywords Angiography Atherosclerosis Cohort studies Computed axial tomography Coronary heart disease Hazard ratio Muscular dystrophies Myocardial infarction Stable coronary artery disease Stenosis ePublished: 17 October 2023 Issue Published: October 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...