Key result
Postural testing and CT reliably differentiate and localize APA from IHA in primary aldosteronism.
Cohort (n=105)
We retrospectively reviewed the clinical features, methods of diagnosis and localization, and results of treatment in 105 patients with primary aldosteronism seen between 1969 and 1981. Coincident with the use of computed tomography (CT), 131I-6-beta-iodomethyl norcholesterol scans (NP-59), and postural response studies, the study group was temporally divided into pre-1976 and post-1976 groups, and subdivided into groups with aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) due to bilateral adrenal hyperplasia. Our results indicate that aldosterone postural response studies and CT differentiate and localize APA and IHA reliably. Adrenalectomy is a safe and effective treatment for APA, whereas medical treatment alone is preferable for IHA.
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Clive S. Grant (1984) conducted a cohort in Primary aldosteronism (n=105). Diagnostic imaging and postural response studies; surgical vs medical treatment was evaluated. Aldosterone postural response studies and CT reliably differentiate and localize aldosterone-producing adenomas (APA) and idiopathic hyperaldosteronism (IHA).
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