Function of the Auditory and Visual Systems, and of Peripheral Nerve, in Rats after Long‐Term Combined Exposure to n‐Hexane and Methylated Benzene Derivatives. II. Xylene

Rats were exposed to xylene, to n-hexane, or to xylene together with n-hexane, each solvent 1000 p.p.m. (1000 + 1000 p.p.m. in mixed exposure), 18 hr/day, 7 days/week during 61 days. Neurophysiological recordings were made 2 days, 4 months, and 10 months after the end of exposure. Exposure to n-hexane alone, or xylene alone, caused a slight loss of auditory sensitivity as recorded by auditory brainstem response 2 days after the exposure. Exposure to n-hexane together with xylene caused persistent loss of auditory sensitivity (7-17 dB; P < 0.05) which was non-additively enhanced (P < 0.01). The latencies of the flash evoked potentials in the group exposed to n-hexane alone were prolonged (re C group) 2 days after exposure, while smaller prolongations were found in the group exposed to xylene together with n-hexane. Exposure to n-hexane alone caused a marked decrease in nerve conduction velocity, while simultaneous exposure to xylene inhibited n-hexane-induced velocity reduction in peripheral nerve (P < 0.01).