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November 1, 2001The Journal of ImmunologyOpen Access

CD8+ Tumor-Infiltrating T Cells Are Deficient in Perforin-Mediated Cytolytic Activity Due to Defective Microtubule-Organizing Center Mobilization and Lytic Granule Exocytosis

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Authors

SRSaša RadojaNYU Langone HealthMSMasanao SaioGunma UniversityDSDavid SchaerBayer (United States)

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Radoja et al. (2001) studied this question.

synapsesocial.com/papers/6a6ac30001245da06ecb493fhttps://doi.org/10.4049/jimmunol.167.9.5042
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cytotoxic T Lymphocytes1988 · 140 citations
  2. 2Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography.1986 · 165 citations
  3. 3Control of Lytic Function by Mitogen-activated Protein Kinase/Extracellular Regulatory Kinase 2 (ERK2) in a Human Natural Killer Cell Line: Identification of Perforin and Granzyme B Mobilization by Functional ERK21998 · 148 citations