Key result
Inactivation of mTORC1, but not mTORC2, in developing mouse muscle causes perinatal death and greatly impinges on injury-induced muscle regeneration in adults.
Why the study?
Although key factors in muscle fiber formation are known, how intracellular signals are coordinated and integrated during development and regeneration remains largely unknown.
Does the elimination of mTORC1 or mTORC2 affect embryonic and adult myogenesis in mouse muscle progenitors?
Population
Mouse muscle progenitors
Comparison
Elimination of essential components of mTORC1 vs mTORC2
Authors
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mTORC1 inhibition may impair muscle regeneration in mice; leaves open relevance to human myopathies or regenerative therapies.
Does the elimination of mTORC1 or mTORC2 affect embryonic and adult myogenesis in mouse muscle progenitors?
mTORC1, but not mTORC2, is an essential regulator of embryonic and adult myogenesis, controlling proliferation and fusion capacity of muscle progenitors.
Rion et al. (2019) studied Muscle regeneration and myogenesis. Inactivation of mTORC1 and mTORC2 was evaluated on Perinatal death and muscle regeneration capacity. Inactivation of mTORC1, but not mTORC2, in developing mouse muscle causes perinatal death and greatly impinges on injury-induced muscle regeneration in adults.
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