The cleavage process of sterol regulatory element binding proteins (SREBPs) shares several characteristics with that of beta-amyloid precursor protein (betaAPP). We studied the secretion of amyloid beta protein (Abeta) from mutant M19 Chinese hamster ovary (CHO) cells that are defective in the site 2 cleavage of SREBPs. The levels as well as the C-terminal properties of Abeta secreted from M19 cells were similar to those from wild-type CHO cells, demonstrating that gamma-cleavage of betaAPP occurs normally in M19 cells. The present data indicated that gamma-secretase of betaAPP and SREBP site 2 protease are distinct enzymes.
No takes yet. Share an insight, caveat, or question.
Tomita et al. (1998) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: