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July 30, 2026FEMS Microbiology ReviewsOpen Access

The Race between Viral Immune Evasion and the MHC Class I Antigen Processing Pathway

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Authors

YYYu YeYZYing Zhang聂聂皓冰

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Overview

Review highlights viral strategies to evade immune detection via MHC-I manipulation, suggesting implications for immunotherapy.

Key Points

  • This review examines how viruses evade detection by the MHC class I antigen processing pathway and the implications for immune responses.
  • Descriptive synthesis of immune evasion mechanisms across DNA and RNA virus families.
  • Analysis of viral strategies that manipulate MHC-I antigen processing and presentation pathways.
  • Integration of concepts such as cross-presentation limits and peptide landscapes in understanding viral control.
  • Viruses deploy multiple strategies to disrupt antigen processing, enhancing their survival and persistence.
  • Coordinated interference includes altering proteasomal peptide generation and MHC-I trafficking.
  • Viral modulation of immune responses affects CTL and NK cell activities, complicating immune detection.

Cite This Study

Ye et al. (2026) studied this question.

synapsesocial.com/papers/6a6af54160e2b924d3ea1382https://doi.org/10.1093/femsre/fuag036
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