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This research aims to compare the early innate immune responses induced by acute (ECTV) and chronic (MCMV) viral infections in lymph nodes.

Single cell characterization of early innate immune responses induced by acute and chronic viral infections 2267604

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Randomized trial shows distinct immune responses in acute and chronic viral infections, suggesting differences in survival outcomes.

This research aims to compare the early innate immune responses induced by acute (ECTV) and chronic (MCMV) viral infections in lymph nodes.
Used unbiased cellular indexing of transcriptome and epitope single cell sequencing (CITEseq) to analyze immune responses.
Examined responses in wild-type C57BL/6 mice infected with ECTV or MCMV via footpad inoculation.
ECTV infection led to expanded and activated NK cell populations and inflammatory monocytes (specific metrics not stated).
MCMV infection displayed a dispersed cluster of low MCMV transcripts across multiple cell populations (specific metrics not stated).
Acute infection with ECTV correlated with enhanced innate immune responses related to survival, whereas MCMV resulted in weaker responses.

Silva et al. (2026) studied this question.

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