Review integrates epidemiological and clinical evidence, indicating increased cardiovascular risks in patients with periodontitis, suggesting need for preventive measures.
This review integrates epidemiological, mechanistic and clinical evidence demonstrating that patients with periodontitis carry higher risks of cardiovascular events than healthy individuals. Literature from major databases was analyzed narratively. Findings indicate higher risks of myocardial infarction, stroke, and atrial fibrillation driven by systemic inflammation, endothelial dysfunction, vascular invasion, oral-gut-vascular, and epigenetic pathways. Biomarkers show diagnostic potential, while therapy improves surrogate outcomes but not hard endpoints. The review integrates evidence to inform risk stratification and prevention strategies.
No takes yet. Share an insight, caveat, or question.
Qi et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: