Key result
IH was observed in all large DRG neurons (23/23) and most medium (11/12) and small (9/20) neurons, with peak IH normalized to surface area significantly greater in large neurons.
The distribution and density of specific ion currents (IH, IIR, ILEAK) vary significantly across different sizes of adult rat dorsal root ganglion neurons, correlating with their action potential properties.
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Size-dependent DRG current profiles in rats extend basic mapping; leaves open human in vivo relevance and therapeutic translation.
Scroggs et al. (1994) studied this question. Neuron diameter (large vs medium/small) vs. Small and medium diameter neurons was evaluated on Presence and properties of IH, IIR, and ILEAK currents. IH was observed in all large DRG neurons (23/23) and most medium (11/12) and small (9/20) neurons, with peak IH normalized to surface area significantly greater in large neurons.
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