Key result
Forskolin and cholera toxin increased action potential duration by 30.5% and 21.2%, respectively, suggesting adenylate cyclase activators prolong calcium-dependent action potentials by reducing a voltage-dependent potassium conductance.
Population
Mouse dorsal root ganglion neurons in culture
Design
Preclinical
Authors
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cAMP activation may modulate sensory neuron excitability; extends adenylate cyclase signaling studies but leaves open in vivo or clinical relevance.
Activators of adenylate cyclase and cAMP prolong calcium-dependent action potentials in mouse sensory neurons by reducing voltage-dependent potassium conductance.
Grega et al. (1987) studied None (in vitro mouse neurons). Adenylate cyclase activators (forskolin, cholera toxin, prostaglandin E1) vs. Baseline (pre-drug application) was evaluated on Action potential duration. Forskolin and cholera toxin increased action potential duration by 30.5% and 21.2%, respectively, suggesting adenylate cyclase activators prolong calcium-dependent action potentials by reducing a voltage-dependent potassium conductance.
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