Bond activation in action: Unprecedented ruthenium-catalyzed oxidative annulations of alkynes through cleavage of CH bonds set the stage for an efficient 1(2H)-isoquinolone synthesis with ample scope (see scheme; tAm=tert-amyl). Mechanistic studies provided strong evidence for a rate-limiting CH bond metalation through carboxylate assistance.
No takes yet. Share an insight, caveat, or question.
Ackermann et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: