Key result
The GALNTL6 rs558129 T/T genotype, MCT1 rs1049434 T/T genotype, and NOS3 rs2070744 T allele and T/T genotype were significantly more prevalent in power athletes compared to controls.
Why the study?
Recent studies have focused on genetic polymorphisms that may influence athlete status, prompting an evaluation of specific candidate polymorphisms.
Are specific candidate genetic polymorphisms associated with power athlete status?
Meta-Analysis
Are specific candidate genetic polymorphisms associated with power athlete status?
Specific genetic polymorphisms, including variants in GALNTL6, MCT1, and NOS3, are significantly associated with power athlete status.
Answers are grounded in this paper and cite their sources.
Observational links between polymorphisms and athlete status require validation; leaves open causal roles in performance.
Recent studies have focused on genetic polymorphisms that may influence athlete status. This meta-analysis aimed to investigate the association between athlete status and specific candidate genetic polymorphisms (AGTR2 rs11091046, FTO rs9939609, GALNTL6 rs558129, GNB3 rs5443, MCT1 rs1049434, NOS3 rs2070744). Only case-control studies collected from PubMed and Web of Science databases, published between 2009 and 2022, were included. A total of 23 studies were included in the meta-analysis according to the criteria of the research, and analyses were performed using random or fixed effects models. Effect size, odds ratio, or risk ratio were evaluated with a suitable 95% confidence interval. The results showed that the GALNTL6 rs558129 T/T genotype, MCT1 rs1049434 T/T genotype, and NOS3 rs2070744 T allele and T/T genotype were more prevalent in power athletes than in controls (p < 0.05). Conversely, the GALNTL6 rs558129 C allele, C/C genotype, and AGTR2 rs11091046 C allele and C/C genotype were more common in the control group. These findings indicate that some genetic polymorphisms may be important markers in athlete status and should be supported by future studies.
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İpekoğlu et al. (2025) conducted a meta-analysis in Power athlete status. Candidate gene polymorphisms (AGTR2, FTO, GALNTL6, GNB3, MCT1, NOS3) vs. Sedentary control individuals was evaluated on NOS3 rs2070744 T allele frequency (Power vs Control) (OR 0.50, 95% CI 0.07-0.93, p=0.022). The GALNTL6 rs558129 T/T genotype, MCT1 rs1049434 T/T genotype, and NOS3 rs2070744 T allele and T/T genotype were significantly more prevalent in power athletes compared to controls.
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