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January 1, 2007Biology of Blood and Marrow TransplantationOpen Access

Allogeneic Bone Marrow Transplantation from Unrelated Human T-Cell Leukemia Virus-I–negative Donors for Adult T-Cell Leukemia/Lymphoma: Retrospective Analysis of Data from the Japan Marrow Donor Program

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Authors

KKKoji KatoKyushu UniversityYKYoshinobu KandaJichi Medical UniversityTETetsuya EtoHamanomachi Hospital

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Implication

Retrospective analysis finds potential of unrelated bone marrow transplantation for adult T-cell leukemia patients.

Key Points

  • This analysis evaluates the effectiveness of unrelated bone marrow transplantation (UBMT) for patients with adult T-cell leukemia/lymphoma (ATLL).
  • Retrospective analysis of 33 ATLL patients treated with UBMT from the Japan Marrow Donor Program (JMDP).
  • Evaluated overall survival (OS), progression-free survival, and cumulative incidences of disease progression and mortality at 1 year post-transplant.
  • Conducted multivariate analysis to identify independent prognostic factors for OS.
  • 1-year overall survival (OS) was 49.5% and progression-free survival was 49.2%.
  • Cumulative incidence of disease progression was 18.6%, and progression-free mortality was 32.3%.
  • Recipient age over 50 years with nonremission at transplantation showed higher rates of treatment-related mortality (P = .044).

Cite This Study

Kato et al. (2007) studied this question.

synapsesocial.com/papers/6a6b3f7847a1bfb288f312a0https://doi.org/10.1016/j.bbmt.2006.09.002
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