Key result
A triglyceride polygenic risk score was a significant predictor of triglyceride levels (beta=0.313, p=1.52E-04) in adults with a 22q11.2 microdeletion, explaining 8.4% of the variance in a multivariable model.
Why the study?
The 22q11.2 microdeletion conveys a 2-fold increased risk for mild-moderate hypertriglyceridemia, but the role of polygenic risk scores for triglycerides in this population was unknown.
Does a triglyceride polygenic risk score predict triglyceride levels in adults with a 22q11.2 microdeletion?
Cohort (n=151)
No
Does a triglyceride polygenic risk score predict triglyceride levels in adults with a 22q11.2 microdeletion?
Effect estimate: beta=0.313
p-value: p=1.52E-04
A polygenic risk score for triglycerides, along with sex and BMI, significantly predicts elevated triglyceride levels in adults with a 22q11.2 microdeletion.
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TG-PRS refines hypertriglyceridemia prediction in 22q11.2 deletion carriers; leaves open whether testing alters management.
Ying et al. (2023) conducted a cohort in 22q11.2 microdeletion and mild-moderate hypertriglyceridemia (n=151). Triglyceride polygenic risk score (TG-PRS) vs. Lower TG-PRS was evaluated on Triglyceride levels (beta=0.313, p=1.52E-04). A triglyceride polygenic risk score was a significant predictor of triglyceride levels (beta=0.313, p=1.52E-04) in adults with a 22q11.2 microdeletion, explaining 8.4% of the variance in a multivariable model.
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