Key result
A novel calibration-free method for computing arterial oxygen saturation based on a light attenuation model was developed and experimentally validated to be efficacious.
A novel analytical method for computing SpO2 eliminates the need for empirical calibration curves, making it independent of patient and sensor parameters.
Novel calibration-free SpO2 method feasible in humans; leaves open prospective validation before clinical adoption.
In present-day pulse oximeters, oxygen saturation in arterial blood( SpO₂)is computed by utilizing an empirical relationship extracted from a calibration curve. The calibration curve is obtained by curve-fitting data acquired from volunteers. A novel method of computation ofSpO₂that does not require the use of a calibration curve is presented in this paper. Based on a model for the attenuation of light through skin, tissue, bone, and blood, suitable processing steps are identified so that the analytical expression derived for the estimation ofSpO₂becomes free of not only patient but sensor-dependent parameters as well. The experimental results presented in this paper establish the efficacy of the proposed method.
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Reddy et al. (2009) studied this question. Calibration-free method of computation of SpO2 vs. Standard calibration curve method was evaluated on Estimation of SpO2. A novel calibration-free method for computing arterial oxygen saturation based on a light attenuation model was developed and experimentally validated to be efficacious.
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