Key result
Cellular DNAJA3 inhibits Foot-and-Mouth Disease Virus replication by inducing lysosomal degradation of VP1 and restoring the IFN-β signaling pathway.
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May guide FMDV antiviral development via DNAJA3; leaves open in vivo validation and clinical translation.
This study pioneeringly determined the antiviral role of DNAJA3 in FMDV. DNAJA3 was found to interact with FMDV VP1 and trigger its degradation via the lysosomal pathway. In addition, this study is also the first to clarify the mechanism by which VP1 suppressed IFN-β signaling pathway by inhibiting the phosphorylation, dimerization, and nuclear translocation of IRF3. Moreover, DNAJA3 significantly abrogated VP1-induced inhibitive effect on the IFN-β signaling pathway. These data suggested that DNAJA3 plays an important antiviral role against FMDV by both degrading VP1 and restoring of IFN-β signaling pathway.
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Zhang et al. (2019) studied Foot-and-Mouth Disease Virus (FMDV). DNAJA3 was evaluated on FMDV replication and IFN-β signaling pathway activity. Cellular DNAJA3 inhibits Foot-and-Mouth Disease Virus replication by inducing lysosomal degradation of VP1 and restoring the IFN-β signaling pathway.
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