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A nanodendritic gold/graphene-based biosensor that can perform fluorescence, SERS and electrochemical tri-modal miRNA detection in a single microdroplet has been developed. The biosensor was used to successfully perform tri-modal quantitative trace miRNA-375 detection, which enormously reduces false positive readings caused by interference and ambiguous signals, and has significant implications for use in precise physiological and pathological diagnosis.
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Song et al. (2019) studied this question.
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