Extremely Tight Binding of a Ruthenium Complex to Glycogen Synthase Kinase 3

Perfect match: An organoruthenium complex with at most a low picomolar binding constant for glycogen synthase kinases 3 is reported, whose binding to the ATP-binding site has been analyzed by X-ray crystallography. The complex, (RRu)-NP549, is one of the most potent protein kinase inhibitors reported to date, almost four orders of magnitude more potent than the related natural product staurosporine.