Key result
A 1 mm decrease in membranous septum length was associated with a significantly higher risk of conduction abnormalities or permanent pacemaker implantation after TAVI (OR 1.60; 95% CI 1.28-1.99; P<0.001).
Why the study?
Permanent pacemaker implantation after TAVI carries significant risks, motivating investigation into whether membranous septum length and its interaction with implantation depth predict post-TAVI conduction abnormalities.
Do shorter membranous septum length and lower ΔMSID predict conduction abnormalities and permanent pacemaker implantation after TAVI?
Meta-Analysis (n=5,740)
Do shorter membranous septum length and lower ΔMSID predict conduction abnormalities and permanent pacemaker implantation after TAVI?
Odds Ratio: 1.6 (95% CI 1.28–1.99)
p-value: p=< 0.001
Shorter membranous septum length and lower difference between MS length and implantation depth strongly predict the need for permanent pacemaker implantation and conduction abnormalities after TAVI.
Shorter membranous septum length may refine TAVI conduction risk stratification; confirms the association in pooled evidence.
BACKGROUND: Permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation (TAVI) is associated with higher risk of mortality and rehospitalization for heart failure. Efforts to prevent conduction abnormalities (CA) requiring PPI after TAVI should be made. The membranous septum (MS) length and its interaction with implantation depth (ID-ΔMSID) could provide useful information about the risk of CA/PPI following TAVI. OBJECTIVES: To identify MS length and ΔMSID as predictors of CA/PPI following TAVI. METHODS: Study-level meta-analysis of studies published by September 30, 2022. RESULTS: Eighteen studies met our eligibility including 5740 patients. Shorter MS length was associated with a significantly higher risk of CA/PPI (per 1 mm decrease: odds ratio [OR] 1.60, 95% confidence interval [CI] 1.28-1.99, p < 0.001). Similarly, lower ΔMSID was associated with a significantly higher risk of CA/PPI (per 1 mm decrease: OR 1.75, 95% CI 1.32-2.31, p < 0.001). Meta-regression analyses revealed a statistically significant modulation of the effect of shorter MS length and lower ΔMSID on the outcome (CA/PPI) by balloon postdilatation (positive regression coefficients with p < 0.001); with increasing use of balloon postdilatation, the effect of shorter MS length and lower ΔMSID on the outcome increased. MS length and ΔMSID demonstrated excellent discriminative abilities, with diagnostic ORs equaling 9.49 (95% CI 4.73-19.06), and 7.19 (95% CI 3.31-15.60), respectively. CONCLUSION: Considering that short MS length and low ΔMSID are associated with higher risk of CA and PPI, we should include measurement of MS length in the pre-TAVI planning with MDCT and try to establish optimal ID values before the procedure to avoid CA/PPI.
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Sá et al. (2023) conducted a meta-analysis in Conduction abnormalities and permanent pacemaker implantation after TAVI (n=5,740). 1 mm decrease in membranous septum (MS) length was evaluated on Conduction abnormalities (CA) or permanent pacemaker implantation (PPI) (OR 1.60, 95% CI 1.28-1.99, p=< 0.001). A 1 mm decrease in membranous septum length was associated with a significantly higher risk of conduction abnormalities or permanent pacemaker implantation after TAVI (OR 1.60; 95% CI 1.28-1.99; P<0.001).
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