Key result
Angiotensin-(1-7) selectively stimulated renal PGI2 release, and inhibition with indomethacin halved the fourfold increase in urine flow and sevenfold increase in sodium excretion rate.
Population
Rat isolated kidneys perfused at 37°C with gassed Krebs-Henseleit buffer
Comparison
Angiotensin- infused at a final concentration of… vs Angiotensin- alone versus Angiotensin- plus…
Design
Preclinical
Follow-up
six 10-minute clearance periods
Authors
Loading...
Ang-(1-7) elicits natriuresis in rat kidney; leaves open any role in human hypertension.
Ang-(1-7) selectively stimulates renal PGI2 release, which partially mediates its natriuretic and diuretic effects, potentially explaining the link between prostaglandins and ACE inhibitors.
Hilchey et al. (1995) studied this question. Angiotensin-(1-7) vs. Angiotensin-(1-7) with indomethacin was evaluated on Renal PGI2 and PGE2 release, urine flow, and sodium excretion rate. Angiotensin-(1-7) selectively stimulated renal PGI2 release, and inhibition with indomethacin halved the fourfold increase in urine flow and sevenfold increase in sodium excretion rate.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: