Key result
Psychosocial-driven frailty pathways explain ~27% of myocardial infarction occurrence.
Why the study?
Although social and psychological variables and frailty increase the risk of myocardial infarction, their simultaneous effect has not been extensively studied.
Do psychosocial factors and frailty interact to predict the occurrence of myocardial infarction in older adults?
Cross-Sectional (n=46,498)
Yes
Do psychosocial factors and frailty interact to predict the occurrence of myocardial infarction in older adults?
Effect estimate: β = 0.52 (path from cardiovascular risk factors to myocardial infarction)
Highlights that cardiovascular risk assessment should incorporate a biopsychosocial approach, recognizing that poor psychosocial well-being contributes to physical frailty and subsequent cardiovascular events.
Hypothesis-generating for biopsychosocial MI pathways in older adults; prospective studies needed before clinical adoption.
Myocardial infarction is one of the main causes of death, and cardiovascular risk factors (CVRFs) are always considered when studying it. However, although it is known that other social and psychological variables, and especially frailty, can increase the risk of infarction, their simultaneous effect has not been extensively studied. This study is based on data from the SHARE project (latest wave, Wave 8), with a representative sample of 46,498 participants aged 50 or older (M = 70.40, SD = 9.33), of whom 57.4% were females. Statistical analyses included a full structural equation model that predicts 27% of infarction occurrence and evidences the significant effect of well-being, depression, and social connectedness on frailty. Frailty, in turn, explains 15.5% of the variability of CVRFs. This work supports the need to study these physical, social, and mental health factors together to intervene on frailty and, in turn, improve cardiovascular outcomes.
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Tomás et al. (2023) conducted a cross-sectional in Myocardial Infarction Risk (n=46,498). Psychosocial factors and frailty was evaluated on Occurrence of myocardial infarction (β = 0.52 (path from cardiovascular risk factors to myocardial infarction)). Psychosocial variables such as well-being and depression significantly predicted frailty, which in turn explained 15.5% of cardiovascular risk factor variability and ultimately predicted 27% of myocardial infarction occurrence.
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