Key result
Highest sdLDL-C/LDL-C ratio quartile linked to ~10-fold higher ASCVD odds vs. lowest quartile.
Why the study?
Is an elevated sdLDL-C/LDL-C ratio associated with increased odds of ASCVD?
Case-Control (n=8,924)
No
Is an elevated sdLDL-C/LDL-C ratio associated with increased odds of ASCVD?
An elevated sdLDL-C/LDL-C ratio is strongly associated with increased odds of ASCVD, potentially serving as a superior predictive marker compared to sdLDL-C alone.
BACKGROUND: Low-density lipoprotein cholesterol (LDL-C) and small dense low-density lipoprotein cholesterol (sdLDL-C) are key drivers of atherosclerotic cardiovascular disease (ASCVD) risk. This study aims to investigate the correlation between sdLDL-C/LDL-C ratio and ASCVD to provide new ideas for accurate prediction of ASCVD and identifying high-risk groups. METHODS: The data were derived from patients who visited the Affiliated Hospital of Inner Mongolia Medical University from January 2019 to July 2023. The relationship between the sdLDL-C/LDL-C ratio and the odds of ASCVD was analyzed using univariate and multivariate logistic regression analysis. Subgroup analysis investigates the potential effects of age, sex, hypertension disease heterogeneity, and the relationship between ASCVD. RESULTS: The study included 8924 subjects with an average age of (59 ± 11) years. Multivariate logistic regression analysis revealed that compared to the lowest quartile of sdLDL-C/LDL-C ratio, the odds of ASCVD increased by 1.39, 3.48, and 9.34 times in quartile groups 2, 3, and 4, respectively (OR values: 2.39 [95% CI 1.91-2.99], 4.48[95% CI 3.59-5.60], 10.34 [95% CI 8.08-13.22]; P < 0.001). This increasing trend was also observed in stratified analyses by age, hypertension and sex. CONCLUSIONS: An elevated sdLDL-C/LDL-C ratio is associated with an increased odds of ASCVD. The ratio's predictive ability for ASCVD occurrence surpasses that of sdLDL-C alone.
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Yang et al. (2025) conducted a case-control in atherosclerotic cardiovascular disease (ASCVD) (n=8,924). sdLDL-C/LDL-C ratio vs. Lowest quartile of sdLDL-C/LDL-C ratio was evaluated on atherosclerotic cardiovascular disease (ASCVD) (OR 10.34, 95% CI 8.08-13.22, p=<0.001). The highest quartile of sdLDL-C/LDL-C ratio was associated with significantly increased odds of ASCVD compared to the lowest quartile (OR 10.34; 95% CI 8.08-13.22; P<0.001).
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