Studies on the constituents of the seeds of Hernandia ovigerd L.. VI. Isolation and structural determination of three lignans.

Three kinds of lignans, including a new lignan, named hernolactone, were isolated from the seeds of Hernandia ovigera L. besides six previously reported lignans, desoxypodophyllotoxin (DPT), desoxypicropodophyllin, bursehernin, podorhizol, hernandin and dehydro-DPT. The structure of hernolactone was determined as (2R, 3R) -3- (4′-hydroxy-3′, 5′-dimethoxybenzyl) -2- (3″, 4″, 5″-trimethoxybenzyl) -γ-butyrolactone (IV) and the other two lignans were identified as (-) -yatein ((-) -deoxypodorhizon) (V) and dehydropodophyllotoxin (IX).