Key result
A computer-enhanced resting electrocardiographic analysis device detected relevant coronary stenosis with 94.8% sensitivity, 86.6% specificity, and an AUC of 0.914 (95% CI 0.868-0.961).
Why the study?
Does a new computer-enhanced 2-lead resting ECG analysis device accurately detect hemodynamically relevant coronary artery stenosis in patients scheduled for coronary angiography?
Observational (n=189)
Yes
Does a new computer-enhanced 2-lead resting ECG analysis device accurately detect hemodynamically relevant coronary artery stenosis in patients scheduled for coronary angiography?
Effect estimate: AUC 0.914 (95% CI 0.868-0.961)
A novel computer-enhanced 2-lead resting ECG analysis device demonstrates high diagnostic accuracy for detecting hemodynamically relevant coronary stenosis compared to invasive angiography.
May support noninvasive stenosis detection in select patients; leaves open routine adoption pending prospective validation.
To assess the sensitivity and specificity of a new computer-enhanced resting electrocardiographic analysis device for the detection of coronary stenosis, 189 patients (aged 61.3+/-12.9 years, 57 women) scheduled for coronary angiography from 4 Asian centers were included in an observational study. Angiographic results were independently classified for hemodynamically relevant stenosis by 2 angiographers. The device calculated a severity score from 0 to 20. The score was significantly higher for patients with coronary stenosis (5.4+/-1.8 vs 1.7+/-2.1). The study device (cutoff 4.0) identified 73 of 77 patients with stenosis (sensitivity 94.8%, specificity 86.6%). Adjusted positive and negative predictive values were 78.4% and 97.1%, respectively (receiver operating characteristic area under the curve, 0.914 [95% confidence interval, 0.868-0.961]). Subgroup analysis showed no significant influence of sex, age, previous revascularization procedures, or participating center. The new computer-enhanced, resting electrocardiographic analysis device appears to identify patients with relevant coronary stenosis with high sensitivity and specificity.
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Hosokawa et al. (2008) conducted an observational in Coronary artery stenosis (n=189). Computer-enhanced resting electrocardiographic analysis device vs. Coronary angiography was evaluated on Detection of hemodynamically relevant coronary stenosis (AUC 0.914, 95% CI 0.868-0.961). A computer-enhanced resting electrocardiographic analysis device detected relevant coronary stenosis with 94.8% sensitivity, 86.6% specificity, and an AUC of 0.914 (95% CI 0.868-0.961).
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