Key result
Heart rate variability parameters, including increased LF/HF ratio and decreased high frequency power, are associated with major depressive disorder and may help predict treatment responsiveness.
Why the study?
Major depressive disorder increases cardiac morbidity and mortality, prompting previous studies on heart rate variability to evaluate MDD and predict treatment outcomes.
Can heart rate variability predict treatment response in patients with major depressive disorder?
Can heart rate variability predict treatment response in patients with major depressive disorder?
Heart rate variability may serve as a useful biomarker for diagnosing and predicting treatment outcomes in patients with major depressive disorder.
May aid MDD monitoring and responsiveness assessment; leaves open prospective validation before clinical adoption.
Major depressive disorder (MDD) is one of the disabling diseases in the world-wide, and known to increase cardiac morbidity and mortality. Therefore, previous studies related heart rate variability (HRV) have been conducted to evaluate and diagnose MDD, and to predict treatment outcomes in patient with MDD. We reviewed extensively on the previous peer-reviewed publications associated with this issue, using Pub-Med. In this review article, we introduce the basic concept of HRV and HRV measures, and present several important findings associated with diagnosis and treatment prediction in MDD with using HRV parameters. Furthermore, we discuss the possible underlying mechanism of this phenomenon, and suggest several considerations for the future research.
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Choi et al. (2020) conducted a review in Major Depressive Disorder. Heart rate variability (HRV) vs. Healthy controls or non-responders was evaluated on Diagnosis of MDD and prediction of treatment response. Heart rate variability parameters, including increased LF/HF ratio and decreased high frequency power, are associated with major depressive disorder and may help predict treatment responsiveness.
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