Key result
Mitochondrial dysfunction is a central feature of human heart failure, emphasizing the need for integrated functional assessments of human cardiac tissue to develop targeted metabolic therapies.
This review highlights methods to evaluate mitochondrial function in the human heart, its role in cardiovascular disease, and potential therapeutic applications.
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Technical barriers limit human cardiac mitochondrial studies; leaves open translation of animal findings to emerging metabolic therapies.
Lemieux et al. (2009) conducted a review in Heart failure and cardiac diseases. Mitochondrial dysfunction is a central feature of human heart failure, emphasizing the need for integrated functional assessments of human cardiac tissue to develop targeted metabolic therapies.
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