Comparative Study of Oral Midazolam vs. Oral Melatonin for Pre-Operative Anxiolysis in Paediatric Patients

BACKGROUND trials with melatonin as a pre-medication agent in anxious children under oxide oxygen sedation for dental treatment have shown good results; but far, only limited data is available. Midazolam is a benzodiazepine which anxiolytic, amnestic, hypnotic and skeletal muscle relaxant effects. We to compare oral midazolam (0.5 mg/Kg) versus oral melatonin (0.5 mg/Kg) a premedication in paediatric patients aged 1-6 years with regard to sedation anxiolysis. is a prospective, randomised double blind clinical study in which sixty children ASA I and II in the age group 1-6 years, scheduled for elective general surgeries included who were randomly allocated to two groups that would receive 0.5 mg/Kg of oral midazolam or 0.5 mg/Kg of oral melatonin. The children evaluated for sedation, anxiolysis, parental separation anxiety and of mask at induction. and melatonin were well accepted by the children. The quality and of sedation were similar in both the groups. The quality of anxiolysis is better in the midazolam group, and the onset is earlier which is significant. Melatonin group had a delayed onset and quality of was satisfactory and comparable to midazolam. The quality of parental and quality of mask acceptance was statistically insignificant in both groups. melatonin can be an alternative premedication for sedation-anxiolysis in . Oral midazolam had earlier onset and superior quality of sedationanxiolysis compared to oral melatonin in the doses compared.