Key result
Alterations in the expression of angiotensin-converting enzymes 1, 2, and 3 may be important mechanisms underlying both female and male infertility.
This review highlights the potential role of angiotensin-converting enzymes in the mechanisms underlying male and female infertility.
ACE alterations may link metabolic syndrome to infertility; leaves open whether RAS modulation affects fertility outcomes.
According to the World Health Organization, infertility, associated with metabolic syndrome, has become a global issue with a 10%-20% incidence worldwide. An accumulating body of evidence has shown that the renin-angiotensin system is involved in the fertility problems observed in some populations. Moreover, alterations in the expression of angiotensin-converting enzyme-1, angiotensin-converting enzyme-2, and angiotensin-converting enzyme-3 might be one of the most important mechanisms underlying both female and male infertility. However, as a pseudogene in humans, further studies are needed to explore whether the abnormal angiotensin-converting enzyme-3 gene could result in the problems of human reproduction. In this review, the relationship between angiotensin-converting enzymes and fertile ability is summarized, and a new procedure for the treatment of infertility is discussed.
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Pan et al. (2013) conducted a review in Infertility. Angiotensin-converting enzymes was evaluated. Alterations in the expression of angiotensin-converting enzymes 1, 2, and 3 may be important mechanisms underlying both female and male infertility.
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