Key result
Peak urinary N-terminal fragment of titin concentration strongly correlated with serum creatine kinase activity (r = 0.90, p < 0.05) following high-intensity eccentric exercise.
Why the study?
To evaluate whether changes in noninvasively assessed urinary N-terminal fragment of titin concentration associate with serum creatine kinase activity and other markers following high-intensity eccentric exercise.
Does urinary N-terminal fragment of titin correlate with serum creatine kinase activity following exercise-induced severe muscle damage in healthy young men?
Observational (n=28)
Does urinary N-terminal fragment of titin correlate with serum creatine kinase activity following exercise-induced severe muscle damage in healthy young men?
Effect estimate: r = 0.90
p-value: p=< 0.05
Urinary N-terminal fragment of titin may serve as a non-invasive surrogate marker for serum creatine kinase activity following exercise-induced severe muscle damage.
U-titin strongly correlates with CK after eccentric exercise; leaves open its role as noninvasive damage marker pending validation.
We aimed to evaluate whether changes in the noninvasively assessed urinary N-terminal fragment of titin (U-titin) concentration may be associated with those of serum creatine kinase (CK) activity, transverse relaxation time (T2), maximal voluntary contraction (MVC) torque, range of motion (ROM), and muscle soreness, following high-intensity eccentric exercise. Twenty-eight healthy young men performed 30 maximal isokinetic (120°/s) eccentric elbow flexor contractions using an isokinetic dynamometer. U-titin concentration, serum CK activity, T2, MVC torque, ROM, and muscle soreness were measured before and after a maximum of 4 days. Both U-titin concentration and serum CK activity increased post-exercise in a similar manner, though the former elevated slightly earlier (p < 0.05). The peak values of log U-titin concentration following eccentric exercise were strongly correlated with those of log serum CK activity (r = 0.90, p < 0.05) and T2 (r = 0.84, p < 0.05). There were moderate correlations between peak values of U-titin concentration and those of MVC torque (r = 0.69, p < 0.05) and ROM decline rate (r = 0.45, p < 0.05). These results suggest that in healthy young men, the non-invasive marker, U-titin, may be used as a serum CK surrogate following exercise-induced severe muscle damage.
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Tanabe et al. (2021) conducted an observational in Exercise-induced severe muscle damage (n=28). High-intensity eccentric exercise vs. Baseline (pre-exercise) was evaluated on Correlation between peak log U-titin concentration and log serum CK activity (r = 0.90, p=< 0.05). Peak urinary N-terminal fragment of titin concentration strongly correlated with serum creatine kinase activity (r = 0.90, p < 0.05) following high-intensity eccentric exercise.
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