Central nervous system bleeding in hemophiliacs

Study Group From an estimated population of 2500 sian and three had underlying congenital hemophiliacs seen between 1965 and anomalies.No etiology was apparent in 976, 71 with documented central ncr-38%.Sixty-five patients had intracranial vous system (CNS) bleeding were studied bleeding.Those with intracerebral bleeding retrospectively: 56 had factor VIII deficiency had a poorer prognosis than did those with and 1 5 had factor IX deficiency.More than subarachnoid or subdural bleeding.Intratwo-thirds were less than 1 8 yr old, and spinal bleeding occurred in six patients.The one-third were age 3 yr or less when CNS combined modality rate was 34%.Of 47 bleeding occurred.Thirty-eight (54%) had survivors, 12 (26%) had recurrent bleeda history of recent trauma; one-half of ing in the absence of known trauma.Rethese had a long symptom-free interval of current bleeding 1 yr or more after the 4 ± 2.2 days ( 1 SD) .Four had hyperten-initial episodes seemed to be more