Key result
Targeted modification of the Apob gene in mice resulted in a hypobetalipoproteinemia phenotype with significantly reduced total cholesterol (50.6 mg/dl vs 111.2 mg/dl) and unexpected developmental abnormalities.
Absolute Event Rate: 50.6% vs 111.2%
p-value: p=<0.0005
Targeted modification of the Apob gene in mice successfully models human hypobetalipoproteinemia but is unexpectedly associated with severe developmental abnormalities.
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Enables mechanistic studies of hypobetalipoproteinemia; leaves open translation to human coronary protection.
Homanics et al. (1993) studied Familial hypobetalipoproteinemia (mouse model). Targeted modification of the Apob gene (homozygous) vs. Wild-type mice was evaluated on Total plasma cholesterol (mg/dl) (p=<0.0005). Targeted modification of the Apob gene in mice resulted in a hypobetalipoproteinemia phenotype with significantly reduced total cholesterol (50.6 mg/dl vs 111.2 mg/dl) and unexpected developmental abnormalities.
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