Key result
Targeted modification of the Apob gene in mice resulted in a hypobetalipoproteinemia phenotype with significantly reduced total cholesterol (50.6 mg/dl vs 111.2 mg/dl) and unexpected developmental abnormalities.
Population
Mice generated using gene targeting to have a modified Apob allele
Design
Preclinical
Authors
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Enables mechanistic studies of hypobetalipoproteinemia; leaves open translation to human coronary protection.
Absolute Event Rate: 50.6% vs 111.2%
p-value: p=<0.0005
Targeted modification of the Apob gene in mice successfully models human hypobetalipoproteinemia but is unexpectedly associated with severe developmental abnormalities.
Homanics et al. (1993) studied Familial hypobetalipoproteinemia (mouse model). Targeted modification of the Apob gene (homozygous) vs. Wild-type mice was evaluated on Total plasma cholesterol (mg/dl) (p=<0.0005). Targeted modification of the Apob gene in mice resulted in a hypobetalipoproteinemia phenotype with significantly reduced total cholesterol (50.6 mg/dl vs 111.2 mg/dl) and unexpected developmental abnormalities.
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