Key result
Caloric restriction and macronutrient-altering dietary strategies are reviewed for their positive effects and mechanisms of action on vascular dysfunction in obesity-associated cardiovascular disease.
Why the study?
Does caloric restriction improve vascular dysfunction and reduce cardiovascular disease risk in obese subjects with metabolic disorders?
Does caloric restriction improve vascular dysfunction and reduce cardiovascular disease risk in obese subjects with metabolic disorders?
Caloric restriction and specific macronutrient alterations are effective dietary interventions for preventing or reducing cardiovascular disease associated with obesity by improving vascular dysfunction.
Caloric restriction (CR) has proved to be the most effective and reproducible dietary intervention to increase healthy lifespan and aging. A reduction in cardiovascular disease (CVD) risk in obese subjects can be already achieved by a moderate and sustainable weight loss. Since pharmacological approaches for body weight reduction have, at present, a poor long-term efficacy, CR is of great interest in the prevention and/or reduction of CVD associated with obesity. Other dietary strategies changing specific macronutrients, such as altering carbohydrates, protein content or diet glycemic index have been also shown to decrease the progression of CVD in obese patients. In this review, we will focus on the positive effects and possible mechanisms of action of these strategies on vascular dysfunction.
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García‐Prieto et al. (2016) conducted a review in Metabolic disorders and obesity. Caloric restriction was evaluated. Caloric restriction and macronutrient-altering dietary strategies are reviewed for their positive effects and mechanisms of action on vascular dysfunction in obesity-associated cardiovascular disease.
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