Key result
Residence in the Northeast region of China was associated with a higher risk of the composite of CHD and stroke in patients with type 2 diabetes compared to the Southwest (OR 2.61; 95% CI 2.38-2.86).
Cross-Sectional (n=219,522)
Yes
Odds Ratio: 2.61 (95% CI 2.38–2.86)
p-value: p=< 0.05
There are significant regional variations in the prevalence of cardiovascular disease among patients with type 2 diabetes in China, with the highest risks observed in the Northeast and North regions.
Regional CVD disparities in Chinese T2DM warrant localized prevention; leaves open causal drivers and intervention effects.
Background: There are large regional variations in the prevalence and mortality of cardiovascular disease in general populations in China. It remains uncertain whether the prevalence in type 2 diabetes mellitus (T2DM) varies by region in China. Methods: We analyzed data of 219,522 Chinese patients with T2DM retrieved from the China National HbA1c Surveillance System in 2012. We used the Chinese population distribution in 2010 to standardize prevalence of coronary heart disease (CHD), stroke, and composite of both in 30 provinces and seven geological regions. Multivariable logistic regression was performed to obtain ORs and CIs of provinces/geological regions for CHD, stroke, and composite of both. Results: Age and sex standardized prevalence of CHD, stroke, and composite of both was, respectively, 4.59% (95% CI, 4.58 to 4.60), 1.79% (1.79 to 1.80), and 5.85% (5.84 to 5.86), in contrast to 0.60% of CHD, 0.80% of stroke, and 1.37% of composite of both in the general population in China. After adjustment for traditional risk factors, Northeast had the highest risks of CHD, stroke, and composite of both, and North had the second highest risks of CHD, stroke, and composite of both among the seven regions, both being higher than any other regions (all P values < 0.05). The ORs of Northeast vs Southwest were up to 2.60 (2.35 to 2.88) for CHD, 2.49 (2.15 to 2.88) for stroke, and 2.61 (2.38 to 2.86) for composite of both. Conclusions: There were large variations in risks of CHD, stroke, and composite of both in T2DM in China with Northeast and North having the highest risks.
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Lyu et al. (2018) conducted a cross-sectional in Type 2 diabetes mellitus (n=219,522). Northeast region residence vs. Southwest region residence was evaluated on Composite of coronary heart disease and stroke (OR 2.61, 95% CI 2.38 to 2.86, p=< 0.05). Residence in the Northeast region of China was associated with a higher risk of the composite of CHD and stroke in patients with type 2 diabetes compared to the Southwest (OR 2.61; 95% CI 2.38-2.86).
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