Key result
Omecamtiv mecarbil exerted contraction-slowing and positive inotropic effects, increased diastolic tension, and increased mitochondrial ROS in rat and human cardiac preparations.
Omecamtiv mecarbil demonstrates complex, condition-dependent effects on contractility and increases mitochondrial ROS in preclinical cardiac models.
We developed a novel setup allowing precise control of preload of EHT and characterized effects of the myosin activator OM. OM not only exerted contraction-slowing and positive inotropic effects but also increased diastolic tension. Effect size and direction varied between species, auxotonic and isometric conditions, concentration, and time. We also observed OM-induced increase of mitochondrial ROS, which has not been observed before and may explain part of the effects on contractility.
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Rhoden et al. (2022) studied this question. Omecamtiv mecarbil was evaluated on Contractility, diastolic tension, and mitochondrial ROS. Omecamtiv mecarbil exerted contraction-slowing and positive inotropic effects, increased diastolic tension, and increased mitochondrial ROS in rat and human cardiac preparations.
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