Conjugate Addition of Amines to an α,β-Unsaturated Imine Derived from α-Aminophosphonate. Synthesis of γ-Amino-α-dehydroaminophosphonates

Aza-Michael reaction of ammonia, aliphatic, aromatic and optically active amines to an alpha,beta-unsaturated imine derived from alpha-aminophosphonate affords alpha-dehydroaminophosphonates with a gamma-stereogenic center bearing an amino group. Resulting gamma-amino alpha-dehydroaminophosphonates can be used for the preparation of phosphorylated pyrimidine derivatives.