Key result
In healthy Cavalier King Charles Spaniels, mean vertebral heart size was 10.08, significantly greater than general canine values (9.7) but less than previous breed-specific values (10.6) (P<0.01).
Why the study?
Breed-specific VLAS, M-VLAS, and RLAD cut-offs had not been reported in Cavalier King Charles Spaniels, a breed predisposed to myxomatous mitral valve disease.
What are the normal breed-specific reference intervals for radiographic heart and left atrial size measurements in healthy Cavalier King Charles Spaniels?
Observational (n=30)
What are the normal breed-specific reference intervals for radiographic heart and left atrial size measurements in healthy Cavalier King Charles Spaniels?
This study establishes breed-specific reference intervals for radiographic heart measurements in healthy Cavalier King Charles Spaniels, which differ from general canine and previously published breed-specific values.
Cavalier King Charles Spaniels (CKCS) are predisposed to developing myxomatous mitral valve disease (MMVD), with radiographs frequently used to screen for evidence of left-sided cardiomegaly secondary to MMVD. Vertebral heart size (VHS), vertebral left atrial size (VLAS), modified VLAS (M-VLAS), and radiographic left atrial dimension (RLAD) are reported as objective measurements of global heart size and left atrial size. Normal VHS in CKCS (10.6 ± 0.5) is reportedly higher than the non-breed-specific value (9.7±0.5). Breed-specific VLAS, M-VLAS, and RLAD cut-offs have not been reported in CKCS. The aim of this prospective reference interval study was to describe the VHS, VLAS, M-VLAS, and RLAD values for 30 clinically healthy adult CKCS. Inclusion criteria were unremarkable physical examination, normal echocardiography, and thoracic radiographs without malposition/abnormalities. There were 22 female and eight male dogs. Ages ranged from 1 to 6 years. The VHS mean value in our sample was 10.08 ± 0.56 (95% range, 9.87-10.29). This was significantly greater than a previously published general canine reference value of 9.7 ± 0.5 and significantly less than a previously published CKCS breed-specific value of 10.6 ± 0.5 (P < 0.01). Mean VLAS, M-VLAS, and the RLAD values in our study were 1.79 ± 0.3 (95% range, 1.68-1.9), 2.23 ± 0.44 (95% range, 2.06-2.39), and 1.2 ± 0.34 (95% range, 1.07-1.33), respectively. These were significantly less than previously published reference interval values (P < 0.001). The VHS, M-VLAS, and the RLAD were not affected by sex, body weight, or BCS; whereas the VLAS was moderately affected by body weight. Findings from this study can be used as background for future thoracic radiographic assessments in CKCS.
No takes yet. Share an insight, caveat, or question.
Bagardi et al. (2021) conducted an observational in Clinically healthy adult Cavalier King Charles Spaniels (n=30). Breed-specific radiographic measurements vs. Previously published reference values was evaluated on Vertebral heart size (VHS) (95% CI 9.87-10.29, p=< 0.01). In healthy Cavalier King Charles Spaniels, mean vertebral heart size was 10.08, significantly greater than general canine values (9.7) but less than previous breed-specific values (10.6) (P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: