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Sonothrombolysis shows promise for acute ischemic stroke clot lysis, but clinical efficacy and safety remain unproven.
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New therapeutic strategies under development aim to improve recanalization rates and clinical outcomes after ischemic stroke. One such approach is ultrasound (US)-enhanced thrombolysis, or sonothrombolysis, which can improve thrombolytic drug actions and even intrinsic fibrinolysis. Although the mechanisms are not fully understood, it is postulated that thrombolysis enhancement is related to nonthermal mechanical effects of US. Recent results indicate that US with or without microbubbles may be effective in clot lysis of ischemic stroke even without additional thrombolytic drugs. Sonothrombolysis is a promising tool for treating acute ischemic stroke, but its efficacy, safety, and technical details have not been elucidated and proved yet in stroke treatment.
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Mijajlović et al. (2013) conducted a review in Ischemic stroke. Sonothrombolysis was evaluated. Sonothrombolysis is a promising tool for clot lysis in acute ischemic stroke, but its clinical efficacy, safety, and technical details remain unproven.
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