Key result
Nuclear localizing anti-DNA antibodies enter living cells through specific cell surface binding to brush border myosin 1, which mediates their endocytosis and subsequent intracellular trafficking.
Population
H35 rat hepatoma cells
Comparison
Monoclonal anti-DNA antibodies (H7, H72, H9) vs Control monoclonal antibody (MOPC-21)
Design
Preclinical
Authors
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Hypothesis-generating for myosin 1 as autoantibody entry target; leaves open clinical relevance pending in vivo validation.
Brush border myosin 1 acts as a specific cell surface receptor mediating the endocytosis and subsequent nuclear localization of a unique subset of anti-DNA autoantibodies.
Yanase et al. (1997) studied Systemic lupus erythematosus. Nuclear localizing anti-DNA antibodies (H7, H72, H9) vs. MOPC-21 (isotype matched control) was evaluated on Cell surface binding and internalization via myosin 1. Nuclear localizing anti-DNA antibodies enter living cells through specific cell surface binding to brush border myosin 1, which mediates their endocytosis and subsequent intracellular trafficking.
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