Key result
Targeting tissue renin-angiotensin pathways offers therapeutic potential by mitigating cellular senescence and inflammation in CVD.
Why the study?
Emerging evidence suggests the tissue renin-angiotensin system is involved in major human disease progression, highlighting the need to examine its therapeutic potential across conditions from an interdisciplinary clinical perspective.
Targeting the protective pathway of the tissue renin-angiotensin system represents a crucial future therapeutic strategy for various cardiovascular and inflammatory diseases.
Evidence has arisen in recent years suggesting that a tissue renin-angiotensin system (tRAS) is involved in the progression of various human diseases. This system contains two regulatory pathways: a pathological pro-inflammatory pathway containing the Angiotensin Converting Enzyme (ACE)/Angiotensin II (AngII)/Angiotensin II receptor type 1 (AGTR1) axis and a protective anti-inflammatory pathway involving the Angiotensin II receptor type 2 (AGTR2)/ACE2/Ang1-7/MasReceptor axis. Numerous studies reported the positive effects of pathologic tRAS pathway inhibition and protective tRAS pathway stimulation on the treatment of cardiovascular, inflammatory, and autoimmune disease and the progression of neuropathic pain. Cell senescence and aging are known to be related to RAS pathways. Further, this system directly interacts with SARS-CoV 2 and seems to be an important target of interest in the COVID-19 pandemic. This review focuses on the involvement of tRAS in the progression of the mentioned diseases from an interdisciplinary clinical perspective and highlights therapeutic strategies that might be of major clinical importance in the future.
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Saravi et al. (2021) conducted a review in Cardiovascular, inflammatory, autoimmune diseases, and COVID-19. Tissue renin-angiotensin system (tRAS) modulation was evaluated. The tissue renin-angiotensin system plays a major role in cellular senescence, inflammation, and cardiovascular diseases; modulating its protective and pathological pathways offers promising therapeutic potential.
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