Soft and weak cooperation: Conformationally flexible organic compounds were found to promote the title transformation. These “soft” organocatalysts, which are able to control processes through the differential activation entropies (ΔΔS≠S−R) of the reactive intermediates, lead to high stereoselectivities without the requirement of fine-tuning the reaction temperatures (see scheme).
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Sohtome et al. (2010) studied this question.
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