Key result
Histological analysis of an 82-year-old man with osteogenesis imperfecta revealed interstitial fibrosis of the myocardium and myxoid changes of the mitral leaflet, suggesting a risk of LV remodeling.
Case Report (n=1)
No
Patients with osteogenesis imperfecta may develop left ventricular remodeling and diastolic dysfunction due to myocardial interstitial fibrosis, in addition to known valvular complications.
May signal unrecognized myocardial fibrosis in osteogenesis imperfecta; leaves open its role in LV remodeling and need for prospective studies.
Mitral and aortic valve regurgitation is commonly found in osteogenesis imperfecta (OI) patients, however, little is known about the myocardial involvement in this disorder. An 82-year-old man with OI developed heart failure and was admitted to our hospital. Echocardiogram revealed severe mitral regurgitation without left ventricular (LV) dilatation, but with LV wall thickening. Histological analysis exhibited interstitial fibrosis of the myocardium in addition to myxoid changes of the mitral leaflet. These findings suggest that OI patients may develop LV remodeling together with diastolic dysfunction.
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Soma et al. (2012) conducted a case report in Osteogenesis imperfecta (n=1). Osteogenesis imperfecta was evaluated on Cardiac pathology and echocardiographic findings. Histological analysis of an 82-year-old man with osteogenesis imperfecta revealed interstitial fibrosis of the myocardium and myxoid changes of the mitral leaflet, suggesting a risk of LV remodeling.
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