Key result
Exercise promotes cardiovascular health by reducing inflammation and oxidative stress while improving mitochondrial function via exerkines.
Why the study?
Physical inactivity is a major cardiovascular risk factor, and challenges remain in elucidating the mechanisms of exercise-improved cardiometabolic health and developing personalized exercise prescriptions.
Does exercise improve cardiovascular health and prevent cardiovascular diseases?
Does exercise improve cardiovascular health and prevent cardiovascular diseases?
Exercise is a safe and efficient strategy for reducing cardiovascular risk and managing cardiovascular diseases through systemic molecular mechanisms.
Answers are grounded in this paper and cite their sources.
Supports exercise in cardiac rehabilitation; extends exerkine mechanisms but leaves open prospective outcome trials.
Physical inactivity is a major risk factor for cardiovascular diseases. Regular exercise is considered a safe, simple, yet efficient strategy to reduce cardiovascular risk factors, prevent cardiovascular diseases and improve cardiovascular health. Exercise acts as a “polypill” for cardiovascular disease prevention and our body has an endogenous “medkit” with unlimited refills of this marvelous polypill. The mechanisms of exercise-induced cardiovascular health include alleviating oxidative stress and inflammation, improving cardiovascular insulin sensitivity and metabolism via activating Akt-eNOS “survival signaling” to reduce cardiovascular susceptibility to injury, in which the improvement of mitochondrial function plays a key role in exercise-induced cardiovascular health effects. Recent studies have shown that exerkines that are secreted from multiple tissues in response to exercise orchestrate multi-organ cross-talk in exercise-induced cardiovascular benefits. Clinically, exercise intervention has become a fundamental strategy in cardiac rehabilitation in recent years. This review highlights the challenges in elucidating the mechanisms underlying exercise-improved cardiometabolic health and perspectives on developing personalized and precise exercise prescription for the prevention and management of cardiovascular diseases.
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Zhang et al. (2021) conducted a review in Cardiovascular diseases. Exercise was evaluated. Exercise improves cardiovascular health and prevents disease by alleviating oxidative stress and inflammation, improving mitochondrial function, and orchestrating multi-organ cross-talk via exerkines.
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