Whole-exome sequencing insights into pulmonary artery sarcoma mimicking pulmonary embolism: a case report and review

Figure 1. (A) CT scan of the chest demonstrated a faint infiltrative shadow in the right lower lung field (red arrow). (B) Repeated CT scan showed inflammation of the right pulmonary was progressing nearly one month later. The right lung is scattered in the flaky blurred shadow with an unclear boundary, which is obvious in the middle and lower lobes (red arrow). (C and D) CT pulmonary angiography revealed extensive intraluminal filling defects in the trunk and branches of the right pulmonary artery (red arrow). No filling defects were observed in the left pulmonary artery.

Figure 2. (A) Increased FDG uptake of PET/CT observed in an intraluminal lesion of the right pulmonary artery (red arrow in A , SUVmax 9.69). (B) Increased FDG uptake observed along the wall of the right lobar (red arrow in B, SUVmax 2.45).

Figure 3. Hematoxylin–eosin staining and immunohistochemistry staining in tumor cells. Notes: (A and B) Hematoxylin–eosin staining (×100, and 400, respectively); (C and D) The tumor cells were positive for vimentin (×100, and 400, respectively); (E and F) The tumor cells were positive for desmin (×100, and 400, respectively); (G and H) The tumor cells were positive for MDM2 (×100, and 400, respectively); (I and J) The tumor cells were positive for P53 (×100, and 400, respectively).

Figure 4. (A and B) After a chemotherapy regimen of pemetrexed, CT scan showed metastasis lesions in the right upper lobe and right lower lobe of the patient. (C and D) CT scan showed metastasis lesions in the right upper lobe and right lower lobe of the patient after two cycles of anlotinib. The red arrows represent the metastasis lesions in the right lung.