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October 7, 2016Journal of Cell Science

The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit

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Key result

The tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for interaction with KCNE4, which causes intracellular retention of the channel.

Population

In vitro models studying the voltage-dependent K+ channel Kv1.3 and KCNE4 subunit in leukocytes

Design

Preclinical

Authors

LSLaura SoléUniversitat de BarcelonaSRSara R. RoigInstitut de Biomedicina de la Universitat de BarcelonaAVAlbert Vallejo-GraciaUniversitat de Barcelona

Discussion

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Implication

May modulate immune cell excitability via Kv1.3 retention; leaves open therapeutic targeting in inflammation.

Structured PICO

P
Population
In vitro models studying the voltage-dependent K+ channel Kv1.3 and KCNE4 subunit in leukocytes
E
Exposure
Analysis of the C-terminal domain of Kv1.3 and its interaction with KCNE4
O
Outcome
Molecular determinants governing the Kv1.3-KCNE4 association and mechanisms of intracellular retention

Identifies the molecular mechanisms by which KCNE4 interacts with and regulates the intracellular retention of Kv1.3 channels in leukocytes.

Cite This Study

Solé et al. (2016) studied this question. KCNE4 co-expression vs. Absence of KCNE4 was evaluated on Molecular interaction and intracellular retention of Kv1.3. The tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for interaction with KCNE4, which causes intracellular retention of the channel.

synapsesocial.com/papers/6a6c155334b735385cb3e2a8https://doi.org/10.1242/jcs.191650
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long QT Syndrome-associated Mutations in the S4-S5 Linker of KvLQT1 Potassium Channels Modify Gating and Interaction with minK Subunits1999 · 109 citations
  2. 2Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits2009 · 18 citations
  3. 3A non-canonical di-acidic signal at the C-terminal of Kv1.3 determines anterograde trafficking and surface expression2013 · 27 citations
  4. 4Kv1.5 Association Modifies Kv1.3 Traffic and Membrane Localization2008 · 69 citations
  5. 5KCNE Regulation of K+ Channel Trafficking – a Sisyphean Task?2012 · 34 citations