Ceramides and Cerebrosides from Ligusticum chuanxiongHort.

Abstract magnified image Two new ceramides, (2 R )‐2‐hydroxy‐ N ‐[(2 S ,3 S ,4 R ,8 E )‐1,3,4‐trihydroxypentadec‐8‐en‐2‐yl]heptacosanamide ( 1 ) and (2 R )‐2‐hydroxy‐ N ‐{(3 S ,4 S ,5 S )‐4‐hydroxy‐5‐[(4 E )‐undec‐4‐en‐1‐yl]tetrahydrofuran‐3‐yl}heptacosanamide ( 2 ), were isolated from the aerial parts of Ligusticum chuanxiong , along with one known ceramide, (2 R )‐2‐hydroxy‐ N ‐[(2 S ,3 S ,4 R ,8 E )‐1,3,4‐trihydroxyicos‐8‐en‐2‐yl]tetracosanamide ( 3 ), and two known cerebrosides, (2 R )‐ N ‐[(2 S ,3 R ,4 E ,8 E )‐1‐( β ‐ D ‐glucopyranosyloxy)‐3‐hydroxydodeca‐4,8‐dien‐2‐yl]‐2‐hydroxydocosanamide ( 4 ) and (2 R )‐ N ‐[(2 S ,3 S ,4 R ,8 E )‐1‐( β ‐ D ‐glucopyranosyloxy)‐3,4‐dihydroxyoctadec‐8‐en‐2‐yl]‐2‐hydroxyhexadecanamide ( 5 ). Their structures were elucidated by extensive spectroscopic analysis, including 1D‐ and 2D‐NMR, as well as HR‐ESI‐MS experiments.