Key result
Del-1 deficiency reduces lung endothelial uptake of platelet microparticles by ~65% in mice.
Why the study?
The physiological role of developmental endothelial locus-1 (Del-1) in the clearance of phosphatidylserine-expressing platelet microparticles by the endothelium was unclear.
Population
Cultured human umbilical vein and microvascular endothelial cells; Del-1-deficient and wild-type mice
Comparison
Del-1 inhibition or deficiency versus wild-type or uninhibited controls
Design
Preclinical in vitro and in vivo experimental study
Authors
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No immediate clinical implications; leaves open Del-1's role in human microparticle clearance.
Absolute Event Rate: 1.09% vs 3.07%
p-value: p=0.02
Del-1 plays a physiological role in the clearance of phosphatidylserine-expressing platelet microparticles by the endothelium.
Dasgupta et al. (2012) studied this question. Del-1 deficiency vs. Wild-type littermates was evaluated on Endothelial cell uptake of platelet microparticles in lung (p=0.02). Del-1-deficient mice had significantly decreased endothelial uptake of platelet microparticles in the lung (1.09 vs 3.07, P=0.02) and liver (1.35 vs 2.85, P=0.01) compared with wild-type mice.
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