Key result
The combination of pocapavir and imocitrelvir shows synergistic antiviral activity and low resistance in vitro, presenting a promising prospect for treating iVDPV excretion.
Why the study?
As wild poliovirus eradication approaches, maintaining a polio-free world requires mitigating the risk of sporadic vaccine-associated paralytic polio by developing antivirals to stop iVDPV excretion in B cell-deficient individuals.
Despite the discovery of promising antiviral candidates for poliovirus, significant clinical and regulatory hurdles remain before they can be approved for mitigating vaccine-associated paralytic polio or prolonged virus shedding.
May inform antiviral strategies for iVDPV; hypothesis-generating and requires clinical trials before practice consideration.
As the world is approaching the eradication of wild poliovirus serotype 1, the last of the three wild types, the question of how to maintain a polio-free world becomes imminent. To mitigate the risk of sporadic vaccine-associated paralytic polio (VAPP) caused by oral polio vaccines (OPVs) that are routinely used in global immunization programs, the Polio Antivirals Initiative (PAI) was established in 2006. The primary goal of the PAI is to facilitate the discovery and development of antiviral drugs to stop the excretion of immunodeficiency-associated vaccine-derived poliovirus (iVDPV) in B cell-deficient individuals. This review summarizes the major progress that has been made in the development of safe and effective poliovirus antivirals and highlights the candidates that have shown promising results in vitro, in vivo, and in clinical trials.
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Xie et al. (2024) conducted a review in Poliovirus infection (VAPP, cVDPV, iVDPV). Poliovirus antivirals (e.g., pocapavir, imocitrelvir) was evaluated. The combination of pocapavir and imocitrelvir shows synergistic antiviral activity and low resistance in vitro, presenting a promising prospect for treating iVDPV excretion.
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