Lethal weapon: The presence of RNA abasic sites generated by ribosome-inactivating proteins (RIPs) such as ricin can be detected. RNA depurination by toxins is signaled by the enhanced emission intensity of synthetically modified emissive RNA constructs that are complementary to the α-sarcin/ricin loop (see picture). This method is more efficient and precise than the use of radiolabeled substrates.
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Srivatsan et al. (2008) studied this question.
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